I recently updated to version 1.4.10-PO on a MacBook Pro running 11.2.3. When the Syrinscape app is in fullscreen, the live area to touch the controls at the bottom (Settings, Info, Edit, Stop, and the 2 volume sliders) are not lining up with the buttons. I figured out I have to click below the actual icon for the button to work.
When the app is used in a window and not fullscreen, the buttons work as expected.