Not at all! Anything you can use with Pathfinder you can use tith Dungeons & Dragons, right?
Syrinscape is actually three separate players - the Fantasy Player, which covers everything sword and sorcery; the Sci-fi Player which runs the gamut of modern games, from high-tech space operas to spaghetti westerns; and the Board Game Player, designed especially to compliment your favourite board games. All three players are free to download and come with free SoundSets.