Can I set the audio output on Syrinscape?

Yes. Syrinscape will stay attached to whichever audio driver is DEFAULT at the moment it starts. Set the audio driver you want Syrinscape to talk to as DEFAULT, then start Syrinscape. After that you are free to change your DEFAULT audio driver and Syrinscape won’t notice. Using this trick, you can point Syrinscape at a virtual audio driver and pipe the audio down a chat client for online play. See more info for online play here